Structural biology has proven to be a highly effective tool for small molecule target identification, drug design, and optimization. It provides key insights for understanding the specific nature of the interaction between a target protein and its potential inhibitor or activator. We use structural biology to guide our target identification and medicinal chemistry optimization.
Our capabilities include:
- Rational design-based protein engineering for improved stability and solubility
- Homology-based molecular modeling
- Computational analysis of function-related conformational changes and structural basis of molecular recognition
- Computational docking and lead optimization (including virtual screening)
- Crystallization of target proteins and their complexes with drug candidates
- 3D structure determination by X-ray diffraction analysis